Free shipping over $99 | Interest Free *no credit check* financing is available!

Gay Man Taking PrEP Daily Has Tested Positive For HIV

by Jeremy Kinser February 25, 2016

PrEP truvada

For the first time, researchers have documented a case in which an individual has contracted a multi-drug resistant strain of HIV.

He claims that at the time he was adhering to a daily regiment of Truvada (tenofovir/emtricitabine) as pre-exposure prophylaxis (PrEP).

POZ reports that scientists have come to the conclusion that it’s indeed possible to contract HIV even when adhering to PrEP, when exposed to a strain of the virus that’s resistant to both drugs included in Truvada.

While it’s concerning, experts are suggesting failures like these will be rare.

David Knox, MD is an HIV specialist at the Maple Leaf Medical Clinic and the head author of the case study.

The findings were first presented at the 2016 Conference on Retroviruses and Opportunistic Infections (CROI) in Boston.

The 43-year-old man had sex with men while taking PrEP once a day.

But after 2 years on Truvada, he tested HIV-positive.

Preliminary tests suggest he was acutely infected.

The man tested positive for the p24 antigen, which surfaces within roughly three weeks of HIV infection and disappears several weeks later.

It was then that he tested negative for HIV antibodies, which typically appear two to eight weeks after infection.

According to POZ:

Research suggests that men who have sex with men (MSM) who take Truvada at least four times a week are more than 99 percent protected against HIV. (CDC guidelines advise taking Truvada daily for maximum protection, but the drug apparently has a good amount of dosing “forgiveness.”) Real-world use of Truvada as HIV prevention has suggested it is indeed highly effective. For example, none of the more than 1,400 generally high-risk individuals taking PrEP through the Kaiser Permanente San Francisco PrEP program have contracted HIV to date, despite their very high rate of other sexually transmitted infections, including hepatitis C virus (HCV) in two of them.

All of PrEP’s power to curb HIV notwithstanding, this new case study underlines the fact that in science there is, unfortunately, no 100 percent guarantee.”

Robert M. Grant, MD, MPH, a professor at the University of California, says, “After 32 years of experience with HIV research, I have learned never to say ‘never’… yet I also think that gay men benefit from feeling safer during sex, and I am grateful that PrEP affords that feeling.”

Pharmacy records demonstrate the man did indeed fill his Truvada prescription regularly.

“This person claims he was taking PrEP every day and I believe him,” said Grant.

Tests suggest the man contracted the virus from a single individual, and while his virus was resistant to multiple drugs, he’s continuing HIV treatment and has a fully suppressed viral load.

Research indicates that resistance to tenofovir, the most commonly prescribed ARV in the world, is increasing. What’s rare is a virus that’s resistant to both tenofovir and emtricitabine, as in this particular case report.

According to Richard Harrigan, PhD, director of the lab program at the British Columbia Center for Excellence in HIV/AIDS in Vancouver, Canada, who was one of the researchers on this case study, “I think we would assume that the efficacy of PrEP would be lower if there is exposure to virus which is resistant to either drug, and lowered further if there is exposure to virus resistant to both drugs.”

“I certainly don’t think that this is a situation which calls for panic. It is an example that demonstrates that PrEP can sometimes be ineffective in the face of drug resistant virus, in the same way that treatment itself can sometimes be ineffective in the face of drug resistant virus.”

“This case demonstrates that while PrEP is beneficial, we can’t rely on it to be an infallible magic bullet.”

 

H/t: LGBTQ Nation




Jeremy Kinser
Jeremy Kinser

Author


Leave a comment

Comments will be approved before showing up.


Also in Think

State Senate Candidate Calls Gay Teen Who Committed Suicide A Murderer, Internet Comes For Him

by Derek de Koff September 29, 2016

The below comment was written by Jason Christensen, a man currently running for Utah State Senate, in regards to a teenager who committed suicide last week over his sexuality: Since being posted on Reddit earlier today, it’s drummed up considerable outrage, with hundreds of people demanding that Christensen’s political career come to an abrupt and inauspicious end. Related: Andrew Christian Model [...]

Continue Reading →

You Can’t Unsee The Hillary “Shimmy Song”

by Jeff Taylor September 29, 2016

Earworm warning: this one will burrow its way into your brain. You’ve seen the shimmy GIFs and memes, now this growing phenomenon has its own song, and it’s…well, kind of annoying actually, but still somewhat amusing. Related: Randy Rainbow Moderates The First Debate; It’s Super The lyrics center around how Hillary Clinton won the first debate [...]

Continue Reading →

Justin Theroux Reflects On Those Infamous ‘Leftovers’ Sweatpants Photos

by Graham Gremore September 29, 2016

It was August 2014. The Leftovers was wrapping up its first season on HBO and the entire Internet was in a tizzy over Justin Theroux’s sweatpants. More specifically, what was flopping around underneath the sweatpants he was wearing in the opening scene of an episode. In case you need a refresher, here you go: After making national headlines, [...]

Continue Reading →